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In Harlem in 1987, Claireece "Precious" Jones is a 16-year-old African American girl born into a life no one would want. She's pregnant for the second time by her absent father, and at home she must wait hand and foot on her mother, an angry woman who abuses her emotionally and physically. School is chaotic and Precious has reached the ninth grade with good marks and a secret – she can't read.

Gabourey Sidibe
Precious

Mo'Nique
Mary

Paula Patton
Ms. Rain

Mariah Carey
Ms. Weiss

Sherri Shepherd
Cornrows

Lenny Kravitz
Nurse John

Stephanie Andujar
Rita

Chyna Layne
Rhonda

Amina Robinson
Jermaine

Xosha Roquemore
Joann

Angelic Zambrana
Consuelo

Aunt Dot
Toosie

Nealla Gordon
Mrs. Lichenstein

Grace Hightower
Socialworker

Barret Helms
Tom Cruise

Kimberly Russell
Katherine

Bill Sage
Mr Wicher

Susan Taylor
Fairy Godmother

Kendall Toombs
Abdul, New Born

Alexander Toombs
Abdul, New Born

Cory Davis
Abdul, 9 Months

Rochelle McNaughton
Aids Clerk

Roy Anthony Tarell Harvey
Boy #1

Abigail Savage
Bunny

Rodney "Bear" Jackson
Carl

Sapphire
Day Care Woman

Linda Watson
Female Clerk

Emani Reid
Girl #1

Dashawn Robinson
Girl #2

AzMarie Livingston
Girl with Jermaine

Maurizio Arseni
Italian Language Instructor

Mugga
KFC Cashier

Chazz Menendez
Man #1 Exits Elevator (St)

Roy T. Anderson
Man #2 Exits Elevator (St)

Quisha Powell
Mongo

Vivien Eng
Nurse

Silje Vallevik
Pretty Blonde Girl

Matthew Bralow
Reggie

Shayla Stewart
Ruby

Erica Faye Watson
Sheila

Ephraim Benton
Skinny Boy #1

Shortee Red
Skinny Boy #2

Timothy Allen
Skinny Boy #3

Nigel Joaquin
Unruly Boy #1

Esley Tate
Unruly Boy #2

Alex Manette
Administrator Harris (uncredited)