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The year is 2087, the setting is the moon. Pluto Nash, the high-flying successful owner of the hottest nightclub in the universe, finds himself in trouble when he refuses to sell his club to lunar gangster Mogan, who just happens to be helping the mysterious Rex Crater mastermind a plan to take over the entire moon.

Eddie Murphy
Pluto Nash

Randy Quaid
Bruno

Rosario Dawson
Dina Lake

Joe Pantoliano
Mogan

Jay Mohr
Tony Francis

Luis Guzmán
Felix Laranga

James Rebhorn
Belcher

Peter Boyle
Rowland

Burt Young
Gino

Miguel A. Núñez Jr.
Miguel

Pam Grier
Flura Nash

John Cleese
James

Victor Varnado
Kelp

Illeana Douglas
Dr. Mona Zimmer

Jacynthe René
Babette

Alissa Kramer
Gina Francis

Heidi Kramer
Filomina Francis

Lillo Brancato
Larry

Alex Sol
Tommy

Doug Spinuzza
Doug

Andrée Fafard
Holographic Spokesmodel

Stu 'Large' Riley
Club Pluto Bouncer

Roc LaFortune
Jimmy

Russell Yuen
Oliver

Bill Corday
Roy

Angela Perzow
Robot Maid

Ezra Franklyn
Robot Thug

Don Jordan
Reporter

Lorca Simons
Pretty Reporter

Eric Hoziel
Johnson

Christopher Bregman
Michalak

Marlon Sterling Long
Lindsey (as Marlon Long)

Mary C. Hammett
Holographic Nurse

Serge Houde
FBI Agent

Jonathan Stark
Desk Clerk

Terry Haig
Security Guard

Roger E. Reid
Pit Boss

Michael Rudder
Croupier

Alex Bisping
Ted Jefferies (as Alexandre Bisping)

Cornelia Sharpe
Tony Francis Fan (as Cornelia Sharpe Bregman)

Mark Camacho
Robot Holding Cell Clerk

Lana Underwood
Sexy Robot

Alec Baldwin
M.Z.M

Linda E. Smith
Dr. Runa Pendanken (uncredited)

Patrick Kerton
Colins (uncredited)

Brian D. Wright
Ed (uncredited)

Brent Donnelly
FBI Agent Spears (uncredited)

Marc Gourdeau
FBI Inspector (uncredited)

Audrey Wasilewski
Waitress (uncredited)

Michael Challenger
Dancer (uncredited)

Elisabetta Fantone
Dancer (uncredited)